The experimental drug NP001 slowed or halted disease progression in some trial participants with ALS; a phase 3 trial is planned for 2013

Posted on Monday, November 5, 2012 - 05:00, By: Amy Madsen
Update (Dec. 12, 2013): In a Dec. 9, 2013, press release, Neuraltus reported that NP001 treatment in the phase 2 trial showed positive trends in slowing ALS progression and that the data support the hypothesis that NP001's primary mechanism of action is restoration of normal function of...

ALS research news briefs, including newly identified roles for TDP43, a new study of the TDP43 mouse, and an ongoing clinical trial of ceftriaxone

Posted on Wednesday, March 23, 2011 - 08:24, By: Margaret Wahl
TDP43 has unexpectedly extensive role Scientists have found that the protein TDP43 normally influences the synthesis of more than 1,500 other proteins, including itself. Mutations in the gene for TDP43 are a known cause of ALS, and TDP43 is depleted in the nucleus and enriched in the cytoplasm (...

ALS can cause people to lose weight, and that's not a good thing

Posted on Tuesday, March 1, 2011 - 11:26, By: Miriam Davidson
In ALS, there is a clear link between weight and survival. Studies show that people who are slightly overweight at the time of diagnosis, and people who maintain their weight through the course of the disease, live longer than those who start out thinner or lose weight as ALS progresses, said Anne-...

Winners with ALS, SMA and LGMD receive support to pursue post-graduate education

Posted on Friday, September 17, 2010 - 14:37, By: Miriam Davidson
Three accomplished scholars determinedly pursuing their educations while living with neuromuscular disease are the first winners of the CMMS Deshae Lott Ministries outreach program scholarships.

Investigators have identified many more cases of ALS due to mutations in the gene for FUS in a variety of ethnic groups.

Posted on Friday, August 13, 2010 - 15:11, By: Margaret Wahl
Mutations in the gene for a protein called FUS may be a more widely distributed cause of amyotrophic lateral sclerosis (ALS) than previously recognized, according to three separate reports, all published in July 2010 in the journal Neurology.

Co-Chair of MDA’s ALS Division writes Reciprocity with toe-operated trackball

Posted on Wednesday, June 16, 2010 - 12:37, By: Miriam Davidson
When MDA ALS Division Co-Chair Augie Nieto was a young businessman just starting out, he had an idea that laid the groundwork for his later, multimillion-dollar success in the fitness industry. Instead of selling his unwanted exercise bikes at a loss, he sent 50 of them as gifts to health club...

Teen with LGMD helps design an accessible beach playground, in honor of an amateur surfer with ALS

Posted on Friday, May 14, 2010 - 12:59, By: Miriam Davidson
Designers of a new accessible beach park in Virginia Beach, Va., are very glad they asked Caroline Pennell, of Chesterfield, to look over their plans. The 14-year-old with limb girdle muscular dystrophy (LGMD) came up with the best idea of all.