This roundup of research news includes information about a possible role for serotonergic neurons in ALS and three strategies for targeting misfolded or aggregated proteins   

Posted on Wednesday, November 14, 2012 - 04:59, By: Amy Madsen
Nerve cells called serotonergic neurons degenerate in amyotrophic lateral sclerosis (ALS) and may influence the ALS disease process, an international research team has reported. In particular, the loss of these specialized cells appears to be linked to increased muscle tone or tightness (spasticity...

Misfolded SOD1 protein, unaccompanied by an SOD1 gene mutation, could underlie at least some cases of sporadic (noninherited) ALS

Posted on Tuesday, October 19, 2010 - 10:24, By: Margaret Wahl
A new study suggests misfolding of the SOD1 protein may be a common contributor not only to familial (inherited) amyotrophic lateral sclerosis (ALS) caused by mutations in the SOD1 gene but to the more common sporadic (noninherited) form of the disease as well.