In amyotrophic lateral sclerosis, abnormal clumps containing the TDP43 protein may originate in one part of brain or spinal cord and spread to other parts

Posted on Wednesday, June 26, 2013 - 16:47, By: Amy Madsen
A team of researchers based at institutions in the United States and Germany has described the path amyotrophic lateral sclerosis (ALS) appears to take as it progresses through different areas of the central nervous system (the brain and spinal cord).
Posted on Wednesday, May 1, 2013 - 09:23, By: Amy Madsen
Update (Feb. 4, 2014): This trial is now closed to new participants. Name: Ozanezumab (GSK1223249) How it works: Ozanezumab, developed by GlaxoSmithKline, is thought to work by helping protect neuromuscular junctions, where muscles interact with nerves. The drug may help repair damaged axons, the...

Mutations in the profilin 1 gene are the cause of familial ALS in 1 to 2 percent of people with the disease

Posted on Friday, July 27, 2012 - 11:19, By: Amy Madsen
A genetic mutation in the gene for a protein called profilin 1 (PFN1) has been identified as a cause of familial amyotrophic lateral sclerosis (ALS), an MDA-supported team of researchers has reported. Only about 5 percent of ALS is familial (where there is a history of ALS in more than one family...