embryonic lethal

Decreased activity of the 'transporter' protein MCT1 appears to result in insufficient energy support and eventual death of motor neurons in ALS research models

Posted on Monday, July 16, 2012 - 06:00, By: Other
Disruption of a “transporter” protein called MCT1 (also SL16A1) leads to the degeneration of muscle-controlling nerve cells (motor neurons) in animal and cell culture models of amyotrophic lateral sclerosis (ALS), an MDA-supported team of researchers has reported. In addition, the team found that...
Posted on Sunday, July 1, 2012 - 09:39, By: Other
Phillip Wong, professor in the departments of pathology and neuroscience at Johns Hopkins University School of Medicine in Baltimore, is working — with MDA support — to develop research mouse models of C9ORF72-related ALS. With colleagues, he plans to use the models to study more closely the...