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Posted on Thursday, September 1, 2011 - 10:35, By: ALSN Staff
Disease 'in a dish' is a new tool for studying ALS
An MDA-supported research team has created a human cellular model of ALS using cells taken from people with the ALS8 subtype of the disease, a familial (inherited) form of ALS (amyotrophic lateral sclerosis) caused by mutations in the VAPB gene.
Treatment with the HDAC inhibitor trichostatin A delayed disease onset and increased survival time in SOD1 research mice
Posted on Thursday, July 28, 2011 - 13:47, By: Amy Madsen
An experimental compound called trichostatin A (TSA) has been shown to improve nerve-cell survival, increase strength and muscle weight, and result in longer life span in mice with a disease resembling ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease).
Studies reveal uniqueness of correlation between longer-than-normal ataxin 2 genes and proteins and increased ALS risk
Posted on Tuesday, June 28, 2011 - 13:52, By: Amy Madsen
In a 2010 study, scientists working in the United States and Germany found that small polyglutamine ("polyQ") expansions of DNA in the ataxin 2 gene significantly increase the risk for developing ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease).
Expansions of DNA coding for glutamine in...
Motor neurons are lost in ALS, but new evidence shows they don't die without significant help from their neighboring cells. These neighbors may be easier to target with therapies than the motor neurons themselves.
Posted on Saturday, May 1, 2010 - 10:04, By: Margaret Wahl
When ALS-affected nerve cells lose function, their closest neighbors can't protect them
Posted on Friday, May 8, 2009 - 14:30, By: Margaret Wahl
A vicious cycle in which damage to nerve cells (neurons) in the spinal cord results in the loss of an important mechanism to protect neurons, causing more neuron loss, has been identified as a possible contributor to ALS (amyotrophic lateral sclerosis). Identification of this pathway opens the...
Posted on Thursday, April 1, 2004 - 07:00, By: Margaret Wahl