immune system

Three short items about the state of ALS science: BrainStorm’s upcoming US stem-cell trial; modifying ALS progression; a blood-based biomarker test

Posted on Wednesday, October 9, 2013 - 05:00, By: Amy Madsen
This roundup of recent amyotrophic lateral sclerosis (ALS) research and clinical trials news includes:

Five short items about the state of ALS science: addressing the way neurodegenerative disease spreads in the body; technology to detect free radicals; the immune system; and more

Posted on Thursday, September 5, 2013 - 05:00, By: Amy Madsen
This roundup of recent MDA-supported amyotrophic lateral sclerosis (ALS) research news and reviews includes:

With funding from MDA, the ALS Therapy Development Institute is testing whether the immune system modulator CTLA4-FC slows disease progression in ALS mice

Posted on Thursday, December 29, 2011 - 06:00, By: Margaret Wahl
The Muscular Dystrophy Association has awarded a $278,850 grant to the ALS Therapy Development Institute (ALS TDI) in Cambridge, Mass., to support testing of a mouse version of a compound called CTLA4-FC in the SOD1 research mouse model of amyotrophic lateral sclerosis (ALS).

The MDA-supported ALS Therapy Development Institute will collaborate with Biogen Idec and UCB to test CDP7657, a compound that modulates the immune system

Posted on Wednesday, December 21, 2011 - 17:04, By: Margaret Wahl
The ALS Therapy Development Institute (ALS TDI), an MDA-supported, nonprofit biotechnology organization dedicated to developing effective treatments for amyotrophic lateral sclerosis (ALS), will collaborate with two major biotechnology companies to investigate a potential treatment that modulates...

An experimental drug targets the immune system in ALS, switching cells from 'attack' to 'protective' mode

Posted on Tuesday, June 15, 2010 - 13:37, By: Amy Madsen
Neuraltus Pharmaceuticals of Palo Alto, Calif., is developing a small molecule whose target is regulation of immune system cells believed to contribute to neuroinflammation and disease progression in ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease). About ALS mechanisms  

Motor neurons are lost in ALS, but new evidence shows they don't die without significant help from their neighboring cells. These neighbors may be easier to target with therapies than the motor neurons themselves.

Posted on Saturday, May 1, 2010 - 10:04, By: Margaret Wahl