Rosa Rademakers

The normal (unmutated) copy of the C9ORF72 gene doesn't appear to be a genetic modifier of ALS or FTD

Posted on Friday, August 10, 2012 - 03:57, By: Amy Madsen
Humans carry two copies of the C9ORF72 gene, each containing a stretch of DNA in which a sequence of DNA building blocks coded GGGGCC is repeated a number of times. (Each six-letter sequence is called a "repeat.") When one of the two copies is mutated so that it contains a far greater than normal...

What we've learned about C90RF72 in ALS

Posted on Sunday, July 1, 2012 - 09:37, By: Other
In September 2011, two research teams working independently added chromosome 9 open reading frame 72 (C9ORF72) to the list of genes that, when mutated, can cause amyotrophic lateral sclerosis (ALS). The finding sparked a great deal of interest in the ALS research community for several reasons,...