SOD1 mouse

ALS TDI's May 2010 research update addressed changes: a new mouse model, new projects, a paradigm shift and a model for faster drug development

Posted on Tuesday, June 1, 2010 - 13:52, By: Amy Madsen
In its quarterly Research Update Webcast on May 18, 2010, the ALS Therapy Development Institute (ALS TDI) informed viewers of a "paradigm shift" in TDI research. The changes include the addition of a new mouse model to the Institute's preclinical drug development program and an increased...

A new type of ALS research mouse, with a mutation in the TDP43 gene, has been developed

Posted on Thursday, October 8, 2009 - 17:14, By: ALSN Staff
Mice carrying a mutation in the gene for the TDP43 protein that's known to cause amyotrophic lateral sclerosis (ALS) in humans have been developed by MDA-supported scientists at Washington University School of Medicine in St. Louis. The mice may provide an important new research tool in this...
Posted on Saturday, September 1, 2007 - 09:16, By: Margaret Wahl
Failure to recognize differences among mice with mutated SOD1 genes may be the key to understanding why so many medications that looked good in mouse studies later failed to benefit humans with ALS, say researchers at the MDA-supported ALS Therapy Development Institute (ALS TDI) in Cambridge,...
Posted on Sunday, July 1, 2007 - 09:16, By: Margaret Wahl
The announcement this spring that yet another promising drug had failed to help people with ALS in a clinical trial has led some in the field to re-examine some assumptions. Minocycline, an antibiotic with anti-inflammatory and anti-cell death properties, had shown positive effects in ALS-...
Posted on Wednesday, July 6, 2005 - 17:00, By: Margaret Wahl
The first real break in solving the mystery of ALS causation came in 1993, when MDA-supported investigators linked one form of familial (genetic) ALS to a gene on chromosome 21 that gives rise to a protein...

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