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MDA-supported researchers report that the small molecule trehalose seems to enhance a cellular waste disposal system in ALS research mice, extending survival and slowing symptom progression
Posted on Thursday, July 25, 2013 - 05:00, By: Amy Madsen
Treatment with a small molecule called trehalose was associated with slower disease progression and longer life span in mice with a disease mimicking amyotrophic lateral sclerosis (ALS), an MDA-supported research team has reported.
Trehalose is a type of sugar composed of two glucose molecules.
Posted on Wednesday, May 1, 2013 - 09:23, By: Amy Madsen
Update (June 16, 2014):
This trial iw now closed to new participants.
Name: Pyrimethamine. This drug is approved by the U.S. Food and Drug Administration for the treatment of malaria and toxoplasmosis; it is marketed under the brand name Daraprim.
Normal SOD1 protein, like mutant SOD1 protein, appears to be prone to misfolding and can cause ALS, at least in mice
Posted on Friday, October 26, 2012 - 05:00, By: Amy Madsen
It's been known since the early 1990s that mutations in the superoxide dismutase-1 (SOD1) gene can result in the production of any number of varieties of improperly folded (misfolded) SOD1 protein, and that these misfolded proteins can cause familial amyotrophic lateral sclerosis (ALS).
The combined effects of astrocytes and SOD1 protein appear to be toxic to motor neurons in models of both inherited and sporadic ALS
Posted on Monday, August 29, 2011 - 17:11, By: Amy Madsen
Astrocytes — cells that normally support and protect nerve cells — have been found to cause motor neuron degeneration in newly created human cellular models of both inherited and noninherited ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease). Scientists tied the astrocytes' effects, in...
A new type of ALS research mouse, with a mutation in the TDP43 gene, has been developed
Posted on Thursday, October 8, 2009 - 17:14, By: ALSN Staff
Mice carrying a mutation in the gene for the TDP43 protein that's known to cause amyotrophic lateral sclerosis (ALS) in humans have been developed by MDA-supported scientists at Washington University School of Medicine in St. Louis. The mice may provide an important new research tool in this...