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Top ALS researchers pinpoint the most formidable challenges in research today and make recommendations to serve as a road map for the future
Posted on Monday, October 7, 2013 - 02:37, By: Amy Madsen
Not all amyotrophic lateral sclerosis (ALS) research happens in laboratories or clinical settings. Scientific conferences also play a central role in the search for ALS treatments and cures.
One important example of this is the Tarrytown II ALS Conference, which was held in Tarrytown, N.Y., in...
Five short items about the state of ALS science addressing: a therapy targeting SOD1; roles for TDP43 in behavior and body fat; respiratory care; and more
Posted on Tuesday, September 24, 2013 - 14:45, By: Amy Madsen
This roundup of recent amyotrophic lateral sclerosis (ALS) research and clinical trials news includes:
Twenty-five new genetic mutations were found in people with sporadic ALS but not in their parents, supporting the role of genetic contribution in the noninherited form of the disease
Posted on Friday, May 31, 2013 - 12:00, By: Amy Madsen
A team of researchers in the U.S. and Australia has shed new light on sporadic amyotrophic lateral sclerosis (ALS), finding that some people with the disorder have gene mutations that may be associated with ALS and that do not exist in either of their parents — so-called de novo mutations.
In a new study, mutations in known familial ALS genes were found to be contributing factors in 11 percent of people with the sporadic form of ALS
Posted on Monday, July 9, 2012 - 12:45, By: Other
In a more than 20-year study of people with amyotrophic lateral sclerosis (ALS), a research team found that 11 percent of people with a diagnosis of sporadic ALS had mutations in genes associated with the familial form of the disease.
What do they mean, and why do they matter?
Posted on Sunday, January 1, 2012 - 12:00, By: Amy Madsen
One of the first things that comes with a diagnosis of ALS is the determination of which “form” a person has: familial or sporadic.
Sometimes it appears obvious. If there’s a known history of the disease “running in the family,” then the person is said to have familial, or inherited, ALS. If the...
The combined effects of astrocytes and SOD1 protein appear to be toxic to motor neurons in models of both inherited and sporadic ALS
Posted on Monday, August 29, 2011 - 17:11, By: Amy Madsen
Astrocytes — cells that normally support and protect nerve cells — have been found to cause motor neuron degeneration in newly created human cellular models of both inherited and noninherited ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease). Scientists tied the astrocytes' effects, in...
Eight researchers share their opinions about the FUS protein and its role in both familial and sporadic ALS
Posted on Friday, July 1, 2011 - 14:22, By: Amy Madsen
How to prevent selective loss of neurons?
Benjamin BrooksCarolinas Medical CenterCharlotte, N.C