Research Administration

Questcor Pharmaceuticals has launched a phase 2 trial to explore the safety and tolerability of H.P Acthar Gel in people with amyotrophic lateral sclerosis

Posted on Thursday, August 1, 2013 - 16:15, By: Amy Madsen
UPDATE (March 3, 2014): This study is closed to new participants.

MDA-supported researchers report that the small molecule trehalose seems to enhance a cellular waste disposal system in ALS research mice, extending survival and slowing symptom progression

Posted on Thursday, July 25, 2013 - 05:00, By: Amy Madsen
Treatment with a small molecule called trehalose was associated with slower disease progression and longer life span in mice with a disease mimicking amyotrophic lateral sclerosis (ALS), an MDA-supported research team has reported. Trehalose is a type of sugar composed of two glucose molecules.

Enrollment is open for a phase 2 trial of a drug normally used to treat abnormal heart rhythms that showed promise in ALS mouse studies

Posted on Monday, July 15, 2013 - 05:00, By: Amy Madsen
Update (June 16, 2014): This trial is now closed to new participants. Update (Jan. 28, 2014): This story has been updated with new contact information for the Boston and St. Louis centers. original story:

58 trial participants mistakenly received a placebo instead of the test drug for part of the BENEFIT-ALS clinical trial of tirasemtiv in ALS

Posted on Monday, July 8, 2013 - 04:35, By: Amy Madsen
Update (Dec. 12, 2013): Cytokinetics announced in a Dec. 8, 2013, press release, that the BENEFIT-ALS trial is now fully enrolled and includes 711 participants. Lead investigator Jeremy Shefner presented a discussion of this study at the 24th International Symposium on ALS/MND, held in Milan,...

Two studies shed light on axonal transport, a critical process for nerve cell survival that appears to malfunction in amyotrophic lateral sclerosis (ALS)

Posted on Wednesday, July 3, 2013 - 05:00, By: Amy Madsen
Axonal transport is the process that is responsible for moving nutrients, proteins and other vital cellular cargo to and from the cell bodies in motor neurons — the muscle-controlling nerve cells that are lost in amyotrophic lateral sclerosis (ALS).

ALS researcher Adriano Chiò discusses what’s been learned about why ALS hurts

Posted on Monday, July 1, 2013 - 09:00, By: Amy Madsen
It used to be said that pain isn't associated with amyotrophic lateral sclerosis (ALS). Used to. Although typically not considered a primary consequence of ALS, researchers and clinicians are realizing that pain does play a role for people with the disease. In fact, in a pair of recent studies...

In amyotrophic lateral sclerosis, abnormal clumps containing the TDP43 protein may originate in one part of brain or spinal cord and spread to other parts

Posted on Wednesday, June 26, 2013 - 16:47, By: Amy Madsen
A team of researchers based at institutions in the United States and Germany has described the path amyotrophic lateral sclerosis (ALS) appears to take as it progresses through different areas of the central nervous system (the brain and spinal cord).

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