ALSN Vol. 17, No. 3

Biomarkers are needed to light the way in research and therapy development

Posted on Sunday, July 1, 2012 - 09:45, By: Other
An urgent need exists for biomarkers — biological indicators — in ALS research that can be used:
Posted on Sunday, July 1, 2012 - 09:41, By: Other
Bryan Traynor Even as some scientists work to develop animal and human cellular models of C9ORF72-related ALS (see C9ORF72 Research Models), others already are targeting the gene with experimental therapies designed to inactivate it or the repeat expansion it harbors.
Posted on Sunday, July 1, 2012 - 09:39, By: Other
Phillip Wong, professor in the departments of pathology and neuroscience at Johns Hopkins University School of Medicine in Baltimore, is working — with MDA support — to develop research mouse models of C9ORF72-related ALS. With colleagues, he plans to use the models to study more closely the...

What we've learned about C90RF72 in ALS

Posted on Sunday, July 1, 2012 - 09:37, By: Other
In September 2011, two research teams working independently added chromosome 9 open reading frame 72 (C9ORF72) to the list of genes that, when mutated, can cause amyotrophic lateral sclerosis (ALS). The finding sparked a great deal of interest in the ALS research community for several reasons,...